Dr Charalampos Babis Kalodimos
Distinguished Professor, University of Minnesota, Biochemistry, Molecular Biology & Biophysics Minneapolis, MN
My lab works on two main directions: first, the determination of the structural and dynamic basis for the function and assembly of large protein machineries; and second, the determination of the role of internal protein dynamics in regulating protein activity and allosteric interactions. Our goal to tackle large and complex systems is arguably a very challenging one. However, obtaining simultaneously structural and dynamic information on these complex systems while at work will pave the way for ultimately understanding how they function. NMR spectroscopy is best suited for providing such invaluable information; nevertheless, its application has been mostly limited to smaller size proteins. We have recently been able to push the envelope by applying NMR to large and very complex biological systems, with the promise to gain unprecedented knowledge of their sophisticated mechanisms of action. For this work I have received the Young Investigator Awards from the Protein Society, the Biophysical Society, and the New York Academy of Sciences, the Stig Sunner Award and the Raymond and Beverly Sackler International Prize in the Physical Sciences.
For more details on Charalampos Babis Kalodimos, please follow this link: kalodimos.cbs.umn.edu