Professor Cynthia Wolberger

Cynthia Wolberger is Professor of Biophysics and Biophysical Chemistry at the Johns Hopkins University School of Medicine.  Dr. Wolberger received her A.B. in Physics from Cornell University and her Ph.D. in Biophysics from Harvard University, where she worked on the structural basis of protein-DNA interactions with Steve Harrison and Mark Ptashne. After a postdoctoral fellowship at the University of California, San Francisco with Bob Stroud, she did further research on the crystal structure analysis of homeodomain-DNA complexes in the laboratory of Carl Pabo at Johns Hopkins and joined the faculty there in 1991. She has done pioneering work on the structural basis for combinatorial regulation of gene expression, the molecular mechanisms of the sirtuin family of protein deacetylases and on ubiquitin signaling. The current focus of her lab’s research is on the mechanisms by which ubiquitin plays a signaling role in transcription and in the DNA damage response. Her laboratory uses a combination of structural, biophysical and biochemical approaches to gain insights into the molecular mechanisms underlying these processes.